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Preclinical imaging is the visualization of living animals for research purposes, [1] such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes.
Endomicroscopy is a technique for obtaining histology-like images from inside the human body in real-time, [1] [2] [3] a process known as ‘optical biopsy’. [4] [5] It generally refers to fluorescence confocal microscopy, although multi-photon microscopy and optical coherence tomography have also been adapted for endoscopic use.
Optoacoustic mesoscopy is suitable for imaging skin lesions. Studies in preclinical models have imaged subcutaneous lesions and their vascular networks and demonstrated the potential to reveal lesion details such as depth, vascular morphology, oxygenation and melanin content.
Imaging Core: The Advanced Imaging Core at MMRI was developed to facilitate the non-invasive analysis of preclinical models of disease. [3] Equipment includes: Perkin Elmer IVIS Spectrum – 2D and 3D optical imaging; Perkin Elmer Quantum GX microCT – x-ray computed tomography imaging; Visual Sonics Vevo 3100 Ultrasound – high frequency ...
The first intravascular in vivo use in a preclinical model was reported in 1994 [6] and first in human, clinical imaging in 2003. [7] The first OCT imaging catheter and system was commercialized by LightLab Imaging, Inc., a company based in Massachusetts formed following a technology transfer in 1997 from Fujimoto's lab (MIT). [8]
Fluorescence imaging is a type of non-invasive imaging technique that can help visualize biological processes taking place in a living organism. Images can be produced from a variety of methods including: microscopy , imaging probes, and spectroscopy .
Model Prototype Surround optical-fiber immunoassay ( SOFIA ) is an ultrasensitive, in vitro diagnostic platform incorporating a surround optical-fiber assembly that captures fluorescence emissions from an entire sample.
High resolution 99m Tc-MDP mouse scan acquired with a stationary SPECT system: animated image of rotating maximum intensity projections.. Preclinical or small-animal Single Photon Emission Computed Tomography is a radionuclide based molecular imaging modality for small laboratory animals [1] (e.g. mice and rats).
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