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Female fertility agents are medications that improve female’s ability to conceive pregnancy. These agents are prescribed for infertile female who fails to conceive pregnancy after 1-year of regular and unprotected sexual intercourse. [1] The following will cover the advancements of female fertility agents, major causes of female infertility.
Progesterone (P4), sold under the brand name Prometrium among others, is a medication and naturally occurring steroid hormone. [20] It is a progestogen and is used in combination with estrogens mainly in hormone therapy for menopausal symptoms and low sex hormone levels in women.
Bioidentical hormones were first used for menopausal symptom relief in the 1930s, [2] after Canadian researcher James Collip developed a method to extract an orally active estrogen from the urine of pregnant women and marketed it as the active agent in a product called Emmenin. [3]
Conjugated estrogens (Premarin) – 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg; Esterified estrogens (Amnestrogen, Estratab, Evex, Femogen, Menest) – 0.3 mg ...
Estradiol enantate is used in combination with the progestin DHPA as a once-monthly combined injectable contraceptive for women in Latin America and Hong Kong. [1] [2] [24] [15] Estradiol enantate has been studied in feminizing hormone therapy for transgender women as well. [25]
[1] [3] It does not bind to sex hormone-binding globulin. [1] [3] Segesterone, the deacetylated form of segesterone acetate, is a metabolite of the medication. [18] The biological half-life of parenteral segesterone acetate has been reported to be 24 to 72 hours. [5] [6] One study specifically reported a biological half-life of 26.8 hours. [6]
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