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Fluphenazine, sold under the brand name Prolixin among others, is a high-potency typical antipsychotic medication. [2] It is used in the treatment of chronic psychoses such as schizophrenia , [ 2 ] [ 3 ] and appears to be about equal in effectiveness to low-potency antipsychotics like chlorpromazine . [ 4 ]
HFC – Human frontal cortex receptor MB – Mouse brain receptor RC – Cloned rat receptor A study measuring the in vivo receptor occupancies of 13 schizophrenic patients treated with 5.7 ± 1.4 mg/day of flupentixol found 50-70% receptor occupancy for D2, 20 ± 5% for D1, and 20 ± 10% for 5-HT2A. [22]
This has the effect of dosing a person who doesn't consent to take the drug. The United Nations Special Rapporteur On Torture has classified this as a human rights violation and cruel or inhuman treatment. [17] The first LAI antipsychotics (often referred to as simply "LAIs") were the typical antipsychotics fluphenazine and haloperidol. [18]
Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia. [3] It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines. [3]
Perphenazine is used to treat psychosis (e.g. in people with schizophrenia and the manic phases of bipolar disorder and OCD). Perphenazine effectively treats the positive symptoms of schizophrenia, such as hallucinations and delusions, but its effectiveness in treating the negative symptoms of schizophrenia, such as flattened affect and poverty of speech, is unclear.
Xanomeline/trospium chloride, sold under the brand name Cobenfy, is a fixed-dose combination medication used for the treatment of schizophrenia. [1] It contains xanomeline, a muscarinic agonist; and trospium chloride, a muscarinic antagonist. [1] Xanomeline is a functionally preferring muscarinic M 4 and M 1 receptor agonist. [1]
This is an accepted version of this page This is the latest accepted revision, reviewed on 7 February 2025. Chemical compound Pharmaceutical compound Pimozide Clinical data Trade names Orap AHFS / Drugs.com Monograph MedlinePlus a686018 License data US FDA: Pimozide Pregnancy category AU: B1 Routes of administration Oral Drug class Typical antipsychotic ATC code N05AG02 (WHO) Legal status ...
Acceptability of treatment Leaving the studies early - any reason Follow-up: 5 weeks: Perazine and the comparison antipsychotic drugs were equally tolerated. These findings are based on data of low quality. RR 0.62 (0.35 to 1.1) Low: No study reported any data on outcomes such as quality of life or information relating to satisfaction with care.