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The mediation of olanzapine in the central nervous system by P-GP means that any other substance or drug that interacts with P-GP increases the risk for toxic accumulations of both olanzapine and the other drug. [98] Olanzapine is a potent antagonist of the muscarinic M 3 receptor, [99] which may underlie its diabetogenic side effects.
Olanzapine/fluoxetine was approved by the U.S. Food and Drug Administration (FDA) to treat the depressive episodes of bipolar I disorder in 2003. [1] In 2009, it was granted approval for the treatment of treatment-resistant depression.
Variations in the indication of a drug may differ between two regions. Based on table 2, there is a broader indication of Olanzapine use in the US. [26] It is approved for treatment-resistant depression and agitation besides of bipolar and Schizophrenia. Whereas in UK, it is only for bipolar and schizophrenia. [27]
The FDA hasn’t approved ketamine to treat bipolar disorder. However, it’s been used off-label to manage pain and depression since the 1970s and may have antidepressant and anti-suicidal ...
[63] [64] Aripiprazole, quetiapine extended-release, and olanzapine (when used in conjunction with fluoxetine) have received the Food and Drug Administration (FDA) labelling for this indication. [65] There is, however, a greater risk of side effects with their use compared to using traditional antidepressants. [63]
Medication that have label indications mean that they were approved by the FDA. This means that they are clinically significant for the indication and manufacturers are allowed to market their drug for the indication. [2] A drug can have more than one FDA labeled indication, which means that it can be used for multiple medical conditions. [5]
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