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It affects women more than men due to the sharp fall in estrogen production that follows menopause. [196] Globally, it is estimated that 21.2% of women and 6.3% of men over the age of 50 have osteoporosis, corresponding to a total of around 500 million people worldwide. [197] About 15% of Caucasians in their 50s and 70% of those over 80 are ...
Fibromyalgia (FM) is a medical syndrome that causes chronic widespread pain, accompanied by fatigue, awakening unrefreshed, and cognitive symptoms. Other symptoms can include headaches, lower abdominal pain or cramps, and depression. [9] People with fibromyalgia can also experience insomnia [10] and general hypersensitivity.
With some myeloma drug therapies, over 30% of people experience a "Grade 3" or higher infection (many people experience multiple such infections), [33] calling for intervention at least by antibiotics. [32] Of people who die within 6 months of their myeloma diagnosis, between 20% and 50% die from collateral infections. [30]
A single 15 mg dose of mirtazapine to healthy volunteers has been found to result in over 80% occupancy of the H 1 receptor and to induce intense sleepiness. [92] After a short period of chronic treatment, however, the H 1 receptor tends to sensitize and the antihistamine effects become more tolerable. Many patients may also dose at night to ...
Some of the oxalate in urine is produced by the body. Calcium and oxalate in the diet play a part but are not the only factors that affect the formation of calcium oxalate stones. Dietary oxalate is found in many vegetables, fruits, and nuts. Calcium from bone may also play a role in kidney stone formation. Calcium phosphate: 10–20%
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5] [6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7]
According to the 2015 Cochrane systematic review, atorvastatin showed greater cholesterol-lowering effect in women than in men compared to rosuvastatin. [50] In children, statins are effective at reducing cholesterol levels in those with familial hypercholesterolemia. [51] Their long term safety is, however, unclear.
But levels of GGT are elevated in only half of men with alcohol use disorder, and it is less commonly elevated in women and younger people. [134] GGT levels remain persistently elevated for many weeks with continued drinking, with a half life of 2-3 weeks, making the GGT level a useful assessment of continued and chronic alcohol use. [ 134 ]