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With stability testing, pharmaceutical industry inspects the quality of drug substances and drug products as per the guidelines outlined by US Food and Drug Administration and International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use to make sure that they retained the quality over the period of time.
Download as PDF; Printable version; In other projects Wikidata item; Appearance. move to sidebar hide. Freeze thaw resistance, or freezing and thawing ...
Freeze tolerance, in which organisms survive the winter by freezing solid and ceasing life functions, is known in a few vertebrates: five species of frogs (Rana sylvatica, Pseudacris triseriata, Hyla crucifer, Hyla versicolor, Hyla chrysoscelis), one of salamanders (Salamandrella keyserlingii), one of snakes (Thamnophis sirtalis) and three of ...
Technicians preparing a body for cryopreservation in 1985. Cryonics (from Greek: κρύος kryos, meaning "cold") is the low-temperature freezing (usually at −196 °C or −320.8 °F or 77.1 K) and storage of human remains in the hope that resurrection may be possible in the future.
Flash freezing is of great importance in atmospheric science, as its study is necessary for a proper climate model for the formation of ice clouds in the upper troposphere, which effectively scatter incoming solar radiation and prevent Earth from becoming overheated by the Sun. [7] The results have important implications in climate control ...
The ability to control intercellular ice formation during freezing is critical to the survival of freeze-tolerant plants. [3] If intracellular ice forms, it could be lethal to the plant when adhesion between cellular membranes and walls occur. The process of freezing tolerance through cold acclimation is a two-stage mechanism: [4]
A thermal shift assay (TSA) measures changes in the thermal denaturation temperature and hence stability of a protein under varying conditions such as variations in drug concentration, buffer formulation (pH or ionic strength), redox potential, or sequence mutation. The most common method for measuring protein thermal shifts is differential ...
Individuals who would like to preserve their future ability to have children often use oocyte cryopreservation to delay and freeze their eggs, allowing them to have children later in life. Individuals diagnosed with cancer who have not yet begun chemotherapy or radiotherapy can also benefit from oocyte cryopreservation. [4]