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Coalescent theory is a model of how alleles sampled from a population may have originated from a common ancestor. In the simplest case, coalescent theory assumes no recombination , no natural selection , and no gene flow or population structure , meaning that each variant is equally likely to have been passed from one generation to the next.
In 1908, G. H. Hardy and Wilhelm Weinberg modeled an idealised population to demonstrate that in the absence of selection, migration, random genetic drift, allele frequencies stay constant over time, and that in the presence of random mating, genotype frequencies are related to allele frequencies according to a binomial square principle called the Hardy-Weinberg law.
Sir John Frank Charles Kingman FRS [4] (born 28 August 1939) [5] is a British mathematician. [2] [6] He served as N. M. Rothschild and Sons Professor of Mathematical Sciences and Director of the Isaac Newton Institute at the University of Cambridge from 2001 until 2006, [1] [5] [7] when he was succeeded by David Wallace.
According to the neutral theory of molecular evolution, an idealised diploid population will have a pairwise nucleotide diversity equal to 4 N e, where is the mutation rate. The effective population size can therefore be estimated empirically by dividing the nucleotide diversity by 4 μ {\displaystyle \mu } . [ 5 ]
Another important branch of population genetics that led to the extensive development of coalescent theory is phylogenetics. Phylogenetics is an area that deals with the reconstruction and analysis of phylogenetic (evolutionary) trees and networks based on inherited characteristics [ 45 ] Traditional population genetic models deal with alleles ...
Two planes sent by Venezuela returned to the country from El Paso, Texas, on Monday with nearly 200 Venezuelans who were in the U.S. illegally.
Coalescence (genetics) or the coalescent theory, the merging of genetic lineages backwards to a most recent common ancestor, in other words a model of how alleles sampled from a population may have originated from a common ancestor
Over 130 years after his gruesome murders in East London, England, the descendants of his victims are looking to unmask the identity of the serial killer popularly known as Jack the Ripper. The ...