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Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy' and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells.
Within this medical field is a special reversal form of drug delivery called chemotactic drug targeting. [ 1 ] [ 2 ] By using chemical agents to help guide a drug carrier to a specific location within the body, this innovative approach seeks to improve precision and control during the drug delivery process, decrease the risk of toxicity, and ...
Spatial ecology of soil microorganisms is a function of their chemotactic sensitivities towards substrate and fellow organisms. [74] [non-primary source needed] [non-primary source needed] The chemotactic behavior of the bacteria was proven to lead to non-trivial population patterns even in the absence of environmental heterogeneities. The ...
The mechanism of the chemorepulsion of immune cells was first acknowledged by medical researchers at the Massachusetts General Hospital in Boston in early 2002. [1] The phenomenon was originally referred to as "reverse chemotaxis ," and later, “fugetaxis” (derived from the Latin words fugere , to flee from; and taxis , movement). [ 1 ]
By chemotactic selection we can determine whether a still not characterized molecule acts via the long- or the short-term receptor pathway. Recent results proved that chemokines (e.g. IL-8 , RANTES ) are working on long-term chemotaxis receptors, while vasoactive peptides (e.g. endothelin ) act more on the short-term ones.
Neutrophils extravasate from blood vessels to the site of tissue injury or infection during the innate immune response.. In immunology, leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes (white blood cells) out of the circulatory system (extravasation) and towards the ...
In cellular biology, haptotaxis (from Greek ἅπτω (hapto) 'touch, fasten' and τάξις (taxis) 'arrangement, order') is the directional motility or outgrowth of cells, e.g. in the case of axonal outgrowth, usually up a gradient of cellular adhesion sites or substrate-bound chemoattractants (the gradient of the chemoattractant being expressed or bound on a surface, in contrast to the ...
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