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Five modern technetium-99m generators The first technetium-99m generator, unshielded, 1958. A Tc-99m pertechnetate solution is being eluted from Mo-99 molybdate bound to a chromatographic substrate. A technetium-99m generator, or colloquially a technetium cow or moly cow, is a device used to extract the metastable isotope 99m Tc of technetium ...
At the hospital, the 99m Tc that forms through 99 Mo decay is chemically extracted from the technetium-99m generator. Most commercial 99 Mo/ 99m Tc generators use column chromatography , in which 99 Mo in the form of water-soluble molybdate, MoO 4 2− is adsorbed onto acid alumina (Al 2 O 3 ).
The metastable technetium-99m (99m Tc) is a short-lived (half-life about 6 hours) nuclear isomer used in nuclear medicine, produced from molybdenum-99. It decays by isomeric transition to technetium-99, a desirable characteristic, since the very long half-life and type of decay of technetium-99 imposes little further radiation burden on the body.
A technetium-99m generator provides the pertechnetate containing the short-lived isotope 99m Tc for medical uses. This compound is generated directly from molybdate held on alumina within the generator (see this topic for detail).
Technetium-99m: A Crucial Diagnostic Tool for Modern Medicine. Technetium-99m is one of the most widely used radiopharmaceuticals in diagnostic imaging due to its ability to provide high-quality, real-time images of internal bodily processes. Its use in various scans, such as bone, renal, cardiac, and neurological scans, makes it indispensable ...
Technetium also has numerous nuclear isomers, which are isotopes with one or more excited nucleons. Technetium-97m (97m Tc; "m" stands for metastability) is the most stable, with a half-life of 91 days and excitation energy 0.0965 MeV. [58] This is followed by technetium-95m (61 days, 0.03 MeV), and technetium-99m (6.01 hours, 0.142 MeV). [58]
99m Tc is a very versatile radioisotope, and is the most commonly used radioisotope tracer in medicine. It is easy to produce in a technetium-99m generator, by decay of 99 Mo. 99 Mo → 99m Tc + e − + ν e. The molybdenum isotope has a half-life of approximately 66 hours (2.75 days), so the generator has a useful life of about two weeks.
Technetium-99m is a gamma emitter. It is obtained on-site at the imaging center as the soluble pertechnetate which is eluted from a technetium-99m generator, and then either used directly as this soluble salt, or else used to synthesize a number of technetium-99m-based radiopharmaceuticals.