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Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
Mebendazole is usually well tolerated. [5] Common side effects include headache, vomiting, and ringing in the ears. [5] If used at large doses it may cause bone marrow suppression. [5] It is unclear if it is safe in pregnancy. [5] [2] Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type. [5]
Mass deworming is one example of mass drug administration. [3] Mass deworming of children can be carried out by administering mebendazole and albendazole which are two types of anthelmintic drug. [5] The cost of providing one tablet every six to twelve months per child (typical doses) is relatively low. [6]
A 2008 review found that the efficacy of single-dose treatments for hookworm infections were as follows: 72% for albendazole, 15% for mebendazole, and 31% for pyrantel pamoate. [29] This substantiates prior claims that albendazole is much more effective than mebendazole for hookworm infections.
Treatment is typically with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. [4] Everyone who lives with or takes care of an infected person should be treated at the same time. [1] Washing personal items in hot water after each dose of medication is recommended. [1]
The mechanisms of antiprotozoal drugs differ significantly drug to drug. For example, it appears that eflornithine, a drug used to treat trypanosomiasis, inhibits ornithine decarboxylase, while the aminoglycoside antibiotic/antiprotozoals used to treat leishmaniasis are thought to inhibit protein synthesis. [8]
A schistosomicide is a drug used to combat schistosomiasis. [1] List. Examples listed in MeSH include: [2] amoscanate; arteether; artemether; chloroxylenol; hycanthone;
Early antiparasitics were ineffective, frequently toxic to patients, and difficult to administer due to the difficulty in distinguishing between the host and the parasite. [ 4 ] Between 1975 and 1999 only 13 of 1,300 new drugs were antiparasitics, which raised concerns that insufficient incentives existed to drive development of new treatments ...