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Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity [5] [6] as an opsonin and via the lectin pathway. Structure
Structure of mannose in its α-D mannopyranose form. Mannan is a polymer of mannose.. The lectin pathway or MBL pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, [1] in that, after activation, it proceeds through the action of C4 and C2 to produce activated complement proteins further down the cascade.
Mannose-binding lectin (MBL) is a soluble innate immune system pattern recognition molecule. [5] MBL activates the complement lectin pathway by binding to glycoconjugates on the surface of a variety of clinically significant bacteria, viruses, and fungi that contain mannose, fucose, or N-acetylglucosamine.
Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. [5] [6] [7]MASP-1 is involved in the lectin pathway of the complement system and is responsible for activating MASP-2 and MASP-3. [8]
Despite the similarities in mannose-binding between the mannose receptor and MBL, these differences suggest that mannose-binding by the mannose receptor evolved separately to that of other C-type lectins. [11] Individually, the CRDs bind mannose with only weak affinity. High affinity binding is thought to result from the clustering of multiple ...
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria.Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation.
Mannan (oligomannan) is a component of the yeast cell wall. Antibodies to yeast mannans are found at increased frequency in Crohn's disease and ASCA positive Crohn's tend to have lower low levels of mannan-binding lectin. [15] Experimentally, antibodies to mannans from yeast can also crossreact to mannans of other types of yeast. [16]
Mannan-binding lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme.