Search results
Results From The WOW.Com Content Network
In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes. It is composed of a group of non-histone proteins that are essential in the structure and maintenance of eukaryotic chromosomes throughout the cell cycle. These scaffold proteins are responsible for the condensation of chromatin during mitosis. [1]
This is an example of a scaffold. Scaffolding is a technique used in bioinformatics. It is defined as follows: [1] Link together a non-contiguous series of genomic sequences into a scaffold, consisting of sequences separated by gaps of known length. The sequences that are linked are typically contiguous sequences corresponding to read overlaps.
the dynamic properties of S/MAR-scaffold contacts as derived by haloFISH investigations [5] the fact that during transcription DNA is reeled through RNA-polymerase which itself is a fixed component of the nuclear matrix [6] the fact that certain domain-intrinsic S/MARs require the support of an adjacent transcription factor to become active. [4]
Chromosome scaffold has important role to hold the chromatin into compact chromosome. Chromosome scaffold is made of proteins including condensin, topoisomerase IIα and kinesin family member 4 (KIF4) [27] Chromosome scaffold constituent proteins are also called scaffold protein. In enzymatic reaction Large multifunctional enzymes that performs ...
Several cell function specific transcription factors (there are about 1,600 transcription factors in a human cell [14]) generally bind to specific motifs on an enhancer [15] and a small combination of these enhancer-bound transcription factors, when brought close to a promoter by a DNA loop, govern level of transcription of the target gene.
In nature, DNA can form three structures, A-, B-, and Z-DNA. A- and B-DNA are very similar, forming right-handed helices, whereas Z-DNA is a left-handed helix with a zig-zag phosphate backbone. Z-DNA is thought to play a specific role in chromatin structure and transcription because of the properties of the junction between B- and Z-DNA.
The non-histone proteins, are a large group of heterogeneous proteins that play a role in organization and compaction of the chromosome into higher order structures. They play vital roles in regulating processes like nucleosome remodeling, DNA replication, RNA synthesis and processing, nuclear transport, steroid hormone action and interphase ...
A eukaryotic cell has a nucleus that separates the processes of transcription and translation. Eukaryotic transcription occurs within the nucleus where DNA is packaged into nucleosomes and higher order chromatin structures. The complexity of the eukaryotic genome necessitates a great variety and complexity of gene expression control.