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Nicotine is an agonist at nicotinic acetylcholine receptor which are present in the central and autonomic nervous systems, and the neuromuscular junction. At low doses nicotine causes stimulatory effects on these receptors, however, higher doses or more sustained exposures can cause inhibitory effects leading to neuromuscular blockade. [4] [30]
Nicotine is a secondary metabolite produced in a variety of plants in the family Solanaceae, most notably in tobacco Nicotiana tabacum, where it can be found at high concentrations of 0.5 to 7.5%. [178] Nicotine is also found in the leaves of other tobacco species, such as Nicotiana rustica (in amounts of 2–14%).
Nicotine products in general have been linked to reproductive harms such as stillbirth, premature birth, and low birth weight. [4] Conversely, non-tobacco-based nicotine pouches (also known as "nic pouches") are classified as non-carcinogenic [5] [6] [7] since nicotine itself is not a carcinogen. However, they are still harmful to ...
"Although nicotine itself is not a carcinogen, we do not know if people who start by using oral nicotine pouches will continue to find them satisfying, or if they will eventually start using more ...
A 2011 report in the International Journal of Environmental Research and Public Health (IJERPH) lists 65 carcinogens or possible carcinogens: "Our list of hazardous smoke components includes all nine components reported in mainstream cigarette smoke that are known human carcinogens (IARC Group I carcinogens), as well as all nine components that ...
Nicotine promotes endothelial cell migration, proliferation, survival, tube formation, and nitric oxide (NO) production in vitro, mimicking the effect of other angiogenic growth factors. In 2001, it was reported that nicotine was a potent angiogenic agent at tissue and plasma concentrations similar to those induced by light to moderate smoking ...
Nicotine is a highly addictive psychoactive chemical. When tobacco is smoked, most of the nicotine is pyrolyzed; a dose sufficient to cause mild somatic dependency and mild to strong psychological dependency remains. The amount of nicotine absorbed by the body from smoking depends on many factors, including the type of tobacco, whether the ...
David Light from Valisure Labs joins The Doctors to share his concerns about finding benzene in products because it’s a group 1 carcinogen and known to cause cancer in humans. David shares a lot ...