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Dextromethorphan (DXM), sold under the trade name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] It affects serotonin, norepinephrine, NMDA, and Sigma-1 receptor receptors in the brain, all of which have been implicated in the pathophysiology of depression.
Side effects of dextromethorphan/bupropion include dizziness, headache, diarrhea, somnolence, dry mouth, sexual dysfunction, and hyperhidrosis, among others. [1] The mechanism of action of dextromethorphan/bupropion in the treatment of depression is unknown.
Recreational use of dextromethorphan. Dextromethorphan, or DXM, a common active ingredient found in many over-the-counter cough suppressant cold medicines, is used as a recreational drug and entheogen for its dissociative effects. [1] Street names include Brownies, Dextro, Drix, Gel, Groove, Lean, Mega-perls, Poor man's ecstasy, Poor man's PCP ...
Ketamine’s antidepressant effects are part of what prompted researchers to explore other drugs that target glutamate—like the venerable cough suppressant dextromethorphan found in Robitussin ...
Anticholinergic. Anticholinergics (anticholinergic agents) are substances that block the action of the acetylcholine (ACh) neurotransmitter at synapses in the central and peripheral nervous system. [1][2] These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells.
Coricidin, Coricidin 'D' (decongestant), or Coricidin HBP (for h igh b lood p ressure), is the name of an over-the-counter cough and cold drug containing dextromethorphan (a cough suppressant) and chlorpheniramine maleate (an antihistamine). [1] Introduced by Schering-Plough in 1949 as one of the first antihistamines, it is now owned by Bayer ...
Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [ 1 ] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C, [ 1 ] but also 5-HT 3, [ 1 ] 5-HT 6, and/or 5-HT 7 in some cases.
Cough and cold medicine, cough syrup, lin, lean. [edit on Wikidata] Cold medicines are a group of medications taken individually or in combination as a treatment for the symptoms of the common cold and similar conditions of the upper respiratory tract. The term encompasses a broad array of drugs, including analgesics, antihistamines and ...