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Allometric scaling is any change that deviates from isometry. A classic example discussed by Galileo in his Dialogues Concerning Two New Sciences is the skeleton of mammals. The skeletal structure becomes much stronger and more robust relative to the size of the body as the body size increases. [13]
Allometric engineering is the process of experimentally shifting the scaling relationships, for body size or shape, in a population of organisms. More specifically, the process of experimentally breaking the tight covariance evident among component traits of a complex phenotype by altering the variance of one trait relative to another.
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Each iteration of the Sierpinski triangle contains triangles related to the next iteration by a scale factor of 1/2. In affine geometry, uniform scaling (or isotropic scaling [1]) is a linear transformation that enlarges (increases) or shrinks (diminishes) objects by a scale factor that is the same in all directions (isotropically).
Kleiber's law, like many other biological allometric laws, is a consequence of the physics and/or geometry of circulatory systems in biology. [5] Max Kleiber first discovered the law when analyzing a large number of independent studies on respiration within individual species. [2]
The square–cube law was first mentioned in Two New Sciences (1638).. The square–cube law (or cube–square law) is a mathematical principle, applied in a variety of scientific fields, which describes the relationship between the volume and the surface area as a shape's size increases or decreases.
The simplest PK compartmental model is the one-compartmental PK model. This models an organism as one homogenous compartment. This monocompartmental model presupposes that blood plasma concentrations of the drug are the only information needed to determine the drug's concentration in other fluids and tissues. For example, the concentration in ...