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ORF3a (previously known as X1 or U274) [2] is a gene found in coronaviruses of the subgenus Sarbecovirus, including SARS-CoV [3] [2] and SARS-CoV-2. [1] [4] It encodes an accessory protein about 275 amino acid residues long, which is thought to function as a viroporin. [1]
Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, the group of viruses cause respiratory tract infections that can range from mild to lethal.
SARS-related coronavirus is a member of the genus Betacoronavirus (group 2) and monotypic of the subgenus Sarbecovirus (subgroup B). [13] Sarbecoviruses, unlike embecoviruses or alphacoronaviruses, have only one papain-like proteinase (PLpro) instead of two in the open reading frame ORF1ab. [14]
The betacoronaviruses of the greatest clinical importance concerning humans are OC43 and HKU1 (which can cause the common cold) of lineage A, SARS-CoV-1 and SARS-CoV-2 (the causes of SARS and COVID-19 respectively) of lineage B, [2] and MERS-CoV (the cause of MERS) of lineage C. MERS-CoV is the first betacoronavirus belonging to lineage C that ...
Prior to the vaccine launch many citizens expressed skepticism that COVID-19 was a serious disease or that their countries had cases or high number of cases of the disease during 2020 and 2021. This prior skepticism that was pushed by the late President of Tanzania , John Pombe Magufuli is seen as a leading reason for vaccine hesitancy within ...
Previous emergence of SARS-CoV-1 and MERS-CoV showed that Betacoronaviruses represent a risk for emergence of diseases threatening to humans. [3] [4] Increased awareness due to the 2002–2004 SARS outbreak motivated research into the potential for other coronavirus outbreaks and the animal reservoirs which could lead to them. [5]
The Enzyme Commission refers to this family as SARS coronavirus main proteinase (M pro; EC 3.4.22.69). The 3CL protease corresponds to coronavirus nonstructural protein 5 (nsp5). The "3C" in the common name refers to the 3C protease (3C pro ) which is a homologous protease found in picornaviruses .
A related coronavirus emerged in Wuhan, China, in November 2019 and spread rapidly around the world. Thought to have originated in bats and subsequently named severe acute respiratory syndrome coronavirus 2, infections with the virus cause a disease called COVID-19, that varies in severity from mild to deadly, [69] and led to a pandemic in 2020.