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Chemical structure of an LNA monomer an additional bridge bonds the 2' oxygen and the 4' carbon of the pentose. A locked nucleic acid (LNA), also known as bridged nucleic acid (BNA), [1] and often referred to as inaccessible RNA, is a modified RNA nucleotide in which the ribose moiety is modified with an extra bridge connecting the 2' oxygen and 4' carbon.
2′-O-methylated ribose causes an increase in the 3′-endo conformation; Pseudouridine (psi/Ψ) adds another option for H-bonding. Heavily methylated RNA is protected from hydrolysis. rRNA acts as a ribozyme by catalyzing its own hydrolysis and splicing.
A bridged nucleic acid (BNA) is a modified RNA nucleotide. They are sometimes also referred to as constrained or inaccessible RNA molecules.BNA monomers can contain a five-membered, six-membered or even a seven-membered bridged structure with a "fixed" C 3 '-endo sugar puckering. [1]
Its favored conformation is at low water concentrations. A-DNAs base pairs are tilted relative to the helix axis, and are displaced from the axis. The sugar pucker occurs at the C3'-endo and in RNA 2'-OH inhibits C2'-endo conformation. [13] Long considered little more than a laboratory artifice, A-DNA is now known to have several biological ...
The Sutherland group's 2009 paper also highlighted the possibility for the photo-sanitization of the pyrimidine-2',3'-cyclic phosphates. [22] A potential weakness of these routes is the generation of enantioenriched glyceraldehyde, or its 3-phosphate derivative (glyceraldehyde prefers to exist as its keto tautomer dihydroxyacetone). [citation ...
Pop Isaacs led Creighton with 27 points while shooting 6-of-9 from the 3-point line. Ashworth added 17 points, eight rebounds and six assists. Dajuan Harris Jr. led Kansas with 15 points and five ...
Somatotype is a theory proposed in the 1940s by the American psychologist William Herbert Sheldon to categorize the human physique according to the relative contribution of three fundamental elements which he termed somatotypes, classified by him as ectomorphic, mesomorphic, and endomorphic.
Pistons G Jaden Ivey undergoes surgery to repair broken fibula after collision with Cole Anthony