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Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both types of organism than third-generation agents. A 2007 meta-analysis suggested when data of trials were combined, mortality was increased in people treated with cefepime compared with other β-lactam antibiotics. [1]
The Composite International Diagnostic Interview – Short Form (CIDI-SF) was first published by Ronald C. Kessler and colleagues in 1998, [4] and the PhenX Toolkit uses this as its adult protocol for general psychiatric assessment. [5] However, the CIDI-SF is no longer supported. [6]
A systematic review of data comparing low-intensity CBT (such as guided self-help by means of written materials and limited professional support, and website-based interventions) with usual care found that patients who initially had more severe depression benefited from low-intensity interventions at least as much as less-depressed patients.
The Center for Scientific Review (CSR) is the portal for United States National Institutes of Health (NIH) grant applications and their review for scientific merit. The CSR organizes the peer review groups or study sections that evaluate the majority (76%) of the research grant applications sent to NIH. [ 1 ]
The World Health Organisation has stated that depression is a leading cause of disability worldwide and a major contributor to the global burden of disease. [5] Stephen Ilardi has described depression as a "disease of civilisation", stating "We were never designed for the sedentary, indoor, sleep-deprived, socially-isolated, fast-food-laden, frenetic pace of modern life".
Scores on the CES-DC range from 0 to 60, in which higher scores suggest a greater presence of depressive symptoms. A score of 15 or higher is interpreted to indicate a risk for depression. However, screening for depression is a complex process and scoring a 15 or higher on the CES-DC should be followed by further evaluation.
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