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Aciclovir, also known as acyclovir, [4] is an antiviral medication. [5] It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. [6] Other uses include, prevention of cytomegalovirus infections following transplant, and severe complications of Epstein–Barr virus infection.
Hepatitis Syndromes in which Ribavirin is active [18] Telaprevir: Hepatitis C Telbivudine (Tyzeka) Hepatitis B: Tenofovir alafenamide: Hepatitis B: Tenofovir disoproxil: Hepatitis B, HIV [19] Tipranavir: HIV Trifluridine: Eyes related Herpes Trizivir: HIV Tromantadine: Herpes Simplex Truvada: HIV Umifenovir: Influenza Valaciclovir (Valtrex) [20 ...
Despite its historical roots in hepatitis C research, the term "direct-acting antivirals" is becoming more broadly used to also include other anti-viral drugs with a direct viral target such as aciclovir (against herpes simplex virus), letermovir (against cytomegalovirus), or AZT (against human immunodeficiency virus).
Mutations in the gene coding thymidine kinase in herpes viruses can endow the virus with resistance to aciclovir. In these situations, alternative medications that are of use include other guanine analogues such as famciclovir, valaciclovir and penciclovir. [4] [5]
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. [1] [2] Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus.
[28] [29] Ribavirin has also been used as a treatment for herpes simplex virus. One small study found that ribavirin treatment reduced the severity of herpes outbreaks and promoted recovery, as compared with placebo treatment. [30] Another study found that ribavirin potentiated the antiviral effect of acyclovir. [31]
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