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Ciprofloxacin, a fluoroquinolone ... is indicated for use in the treatment of acute otitis media and acute otitis externa ... adverse effects of phase I studies ...
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a number of bacterial infections. [5] This includes bone and joint infections, intra-abdominal infections, certain types of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. [5]
Otitis externa, also known as swimmer's ear, is an inflammation (infectious or non-infectious) of the external auditory canal. [14] Risk factors include retained water in the outer ear, particularly due to swimming, humidity, trauma or external devices, dermatologic conditions, or scratching the ear canal that may lead to bacterial growth.
On 12 May 2016, the FDA issued a drug safety communication advising that fluoroquinolones should be reserved for these conditions only when no other options are available due to potentially permanent, disabling side effects occurring together. The drug safety communication also announced the required labeling updates to reflect this new safety ...
Otitis externa; Other names: External otitis, swimmer's ear [1] A moderate case of otitis externa. There is narrowing of the ear channel, with a small amount of exudate and swelling of the outer ear. Specialty: Otorhinolaryngology: Symptoms: Ear pain, swelling of the ear canal, decreased hearing, [2] difficulty chewing: Types: Acute, chronic [2 ...
Finafloxacin is used to treat a type of ear infection called acute otitis externa caused by Pseudomonas aeruginosa and Staphylococcus aureus bacteria. [3] In the clinical trial that led to the drug's approval, finafloxacin shortened the time to cessation of ear pain from an average of 6.8 days in patients taking a placebo to 3.5 days.
The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place. [14]
The most common aetiology of acute otitis externa is bacterial infection, [5] while chronic cases are often associated with underlying skin diseases such as eczema or psoriasis. [6] A third form, malignant otitis externa, or necrotising otitis externa, is a potentially life-threatening, invasive infection of the external auditory canal and ...