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Alka-Seltzer is an effervescent antacid and pain reliever owned by Bayer since 1978. First marketed by the Dr. Miles Medicine Company of Elkhart, Indiana, United States, Alka-Seltzer contains three active ingredients: aspirin (acetylsalicylic acid or ASA), sodium bicarbonate, and anhydrous citric acid. [1]
It originally contained sodium bromide and acetanilide, both toxic substances which were eventually removed. Its current formulation contains the pain reliever aspirin and two reactive chemicals – sodium bicarbonate and citric acid – which creates effervescence when mixed with water. Sodium bicarbonate is an antacid.
Aspirin or other over-the-counter analgesics are widely recognized as effective for the treatment of tension headaches. [96] Aspirin, especially as a component of an aspirin/paracetamol/caffeine combination, is considered a first-line therapy in the treatment of migraine, and comparable to lower doses of sumatriptan. It is most effective at ...
Sodium bicarbonate (IUPAC name: sodium hydrogencarbonate [9]), commonly known as baking soda or bicarbonate of soda, is a chemical compound with the formula NaHCO 3. It is a salt composed of a sodium cation (Na +) and a bicarbonate anion (HCO 3 −). Sodium bicarbonate is a white solid that is crystalline but often appears as a
ATC code B05 Blood substitutes and perfusion solutions is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Sodium bicarbonate is given in a significant aspirin overdose (salicylate level greater than 35 mg/dL 6 hours after ingestion) regardless of the serum pH, as it enhances elimination of aspirin in the urine. It is given until a urine pH between 7.5 and 8.0 is achieved.