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Phosphatidylserine (PS) is the major acidic phospholipid class that accounts for 13–15% of the phospholipids in the human cerebral cortex. [7] In the plasma membrane, PS is localized exclusively in the cytoplasmic leaflet where it forms part of protein docking sites necessary for the activation of several key signaling pathways.
19210 Ensembl ENSG00000156471 ENSMUSG00000021518 UniProt P48651 Q99LH2 RefSeq (mRNA) NM_014754 NM_001290225 NM_008959 RefSeq (protein) NP_001277154 NP_055569 NP_032985 Location (UCSC) Chr 8: 96.26 – 96.34 Mb Chr 13: 67.08 – 67.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphatidylserine synthase 1 is a protein that in humans is encoded by the PTDSS1 gene. Function The ...
Other names in common use include phosphatidylserine synthase, CDPdiglyceride-serine O-phosphatidyltransferase, PS synthase, cytidine 5'-diphospho-1,2-diacyl-sn-glycerol, (CDPdiglyceride):L-serine O-phosphatidyltransferase, phosphatidylserine synthetase, CDP-diacylglycerol-L-serine O-phosphatidyltransferase, cytidine diphosphoglyceride-serine O ...
Phospholipid synthesis occurs in the cytosolic side of ER membrane [15] that is studded with proteins that act in synthesis (GPAT and LPAAT acyl transferases, phosphatase and choline phosphotransferase) and allocation (flippase and floppase). Eventually a vesicle will bud off from the ER containing phospholipids destined for the cytoplasmic ...
Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The phosphatidylserine decarboxylation pathway is the main source of synthesis for phosphatidylethanolamine in the membranes of the mitochondria. Phosphatidylethanolamine produced in the mitochondrial membrane is also ...
L-serine-phosphatidylethanolamine phosphatidyltransferase (EC 2.7.8.29, phosphatidylserine synthase 2, serine-exchange enzyme II, PTDSS2 (gene)) is an enzyme with systematic name L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase. [1] [2] This enzyme catalyses the following chemical reaction
Besides de novo synthesis, PA can be formed in three ways: By phospholipase D (PLD), via the hydrolysis of the P-O bond of phosphatidylcholine (PC) to produce PA and choline. [4] By the phosphorylation of diacylglycerol (DAG) by DAG kinase (DAGK). By the acylation of lysophosphatidic acid by lysoPA-acyltransferase (LPAAT); this is the most ...
The synthesis of Phosphatidylinositol (PI) is limited to the Endoplasmatic Reticulum (ER), which is the largest membrane component of the cell. [23] This site also contributes the synthesis to the majority of phospholipids, namely phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and triacylglycerol (TG). [24]