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Gastrin is a linear peptide hormone produced by G cells of the duodenum and in the pyloric antrum of the stomach.It is secreted into the bloodstream. The encoded polypeptide is preprogastrin, which is cleaved by enzymes in posttranslational modification to produce progastrin (an intermediate, inactive precursor) and then gastrin in various forms, primarily the following three:
A G cell or gastrin cell is a type of cell in the stomach and duodenum that secretes gastrin. It works in conjunction with gastric chief cells and parietal cells . G cells are found deep within the pyloric glands of the stomach antrum , and occasionally in the pancreas [ 1 ] and duodenum .
The human gastrointestinal tract consists of the esophagus, stomach, and intestines, and is divided into the upper and lower gastrointestinal tracts. [3] The GI tract includes all structures between the mouth and the anus , [ 4 ] forming a continuous passageway that includes the main organs of digestion, namely, the stomach , small intestine ...
The effects range from excitatory or inhibitory effects on motility and secretion to feelings of satiety or hunger when acting on the brain. These hormones fall into three major categories, the gastrin and secretin families, with the third composed of all the other hormones unlike those in the other two families. Further information on the GI ...
The glands contain mucous cells and G cells that secrete gastrin. [8] The pylorus also contains scattered parietal cells and neuroendocrine cells. These endocrine cells include D cells, which release somatostatin, [9] responsible for shutting off acid secretion. (There is a second hormone-sensitive population near the fundus.) Unstriated ...
Enteroendocrine cells are specialized cells of the gastrointestinal tract and pancreas with endocrine function. They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for systemic effect, diffuse them as local messengers, or transmit them to the enteric nervous system to activate nervous responses.
The human stomach can be divided into four sections, beginning at the cardia followed by the fundus, the body and the pylorus. [7] [8] The gastric cardia is where the contents of the esophagus empty from the gastroesophageal sphincter into the cardiac orifice, the opening into the gastric cardia.
The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body.