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A bottle of lithium medicine containing 300 mg capsules of lithium carbonate.. In 1970, lithium was approved by the United States Food and Drug Administration (FDA) for the treatment of bipolar disorder, which remains its primary use in the US.
Lithium carbonate is an inorganic compound, the lithium salt of carbonic acid with the formula Li 2 CO 3. This white salt is widely used in processing metal oxides. It is on the World Health Organization's List of Essential Medicines [7] for its efficacy in the treatment of mood disorders such as bipolar disorder. [8] [7]
FDA approved for bipolar disorder maintenance therapy, not for acute mood problems like depression or mania/hypomania. [10] The usual target dose is 100–200 mg daily, titrated to by 25 mg increments every 2 weeks. [11] Lamotrigine can cause Stevens–Johnson syndrome, a very rare but potentially fatal skin condition. [10] Carbamazepine
Bipolar disorder is a long-term mood disorder characterized by major fluctuations in mood — both high and low — that can impact daily functioning and behavior. Bipolar Disorder: 4 Types & What ...
A recent large-scale study found that severe depression in patients with bipolar disorder responds no better to a combination of antidepressant medications and mood stabilizers than it does to mood stabilizers alone and that antidepressant use does not hasten the emergence of manic symptoms in patients with bipolar disorder. [40]
The new understanding of bipolar disorder, and the introduction of lithium as a treatment for it, weren’t the only big changes in psychiatry during the 1960s and 1970s.
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