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Glucose uptake is the process by which glucose molecules are transported from the bloodstream into cells through specialized membrane proteins called glucose transporters, primarily via facilitated diffusion or active transport mechanisms: [1]
In pancreatic beta cells, free flowing glucose is required so that the intracellular environment of these cells can accurately gauge the serum glucose levels. All three monosaccharides (glucose, galactose, and fructose) are transported from the intestinal mucosal cell into the portal circulation by GLUT2. Is a high-frequency and low-affinity ...
The transport of glucose across the proximal tubule cell membrane involves a complex process of secondary active transport (also known as co-transport). [3] This process begins with the Na + /K + ATPase on the basolateral membrane. This enzyme uses ATP to pump 3 sodium ions out of the cell into the blood while bringing 2 potassium ions into the ...
Active transport is highly selective and regulated, with different transporters specific to different molecules or ions. Dysregulation of active transport can lead to various disorders, including cystic fibrosis, caused by a malfunctioning chloride channel, and diabetes, resulting from defects in glucose transport into cells.
Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. [1] GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells. [2]
When the insulin binds to these alpha subunits, 'glucose transport 4' (GLUT4) is released and transferred to the cell membrane to regulate glucose transport in and out of the cell. With the release of GLUT4, the allowance of glucose into cells is increased, and therefore the concentration of blood glucose might decrease.
Once glucose enters the cell, the first step is phosphorylation of glucose by a family of enzymes called hexokinases to form glucose 6-phosphate (G6P). This reaction consumes ATP, but it acts to keep the glucose concentration inside the cell low, promoting continuous transport of blood glucose into the cell through the plasma membrane transporters.
Increased insulin levels cause the uptake of glucose into the cells. GLUT4 is stored in the cell in transport vesicles, and is quickly incorporated into the plasma membrane of the cell when insulin binds to membrane receptors. [24] Under conditions of low insulin, most GLUT4 is sequestered in intracellular vesicles in muscle and fat cells.