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Shingles, also known as herpes zoster or zona, [6] is a viral disease characterized by a painful skin rash with blisters in a localized area. [2] [7] Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. [1]
Shingles vaccination is the only way for adults to be protected against both shingles and postherpetic neuralgia, with two vaccines approved for use in people over age 50. [3] The zoster vaccine Shingrix provides around 90% protection from postherpetic neuralgia, and has been used in many countries since 2017.
Brivudine is used for the treatment of herpes zoster in adult patients. It is taken orally once daily, in contrast to aciclovir, valaciclovir and other antivirals. [1] A study has found that it is more effective than aciclovir, but this has been disputed because of a possible conflict of interest on part of the study authors.
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It causes chickenpox (varicella) commonly affecting children and young adults, and shingles (herpes zoster) in adults but rarely in children. As a late complication of VZV infection, Ramsay Hunt syndrome type 2 may develop in rare cases. VZV infections are species-specific to humans. The virus can survive in external environments for a few hours.
Being exposed to chickenpox as an adult (for example, through contact with infected children) may boost immunity to shingles. Therefore, it was thought that when the majority of children were vaccinated against chickenpox, adults might lose this natural boost, so immunity would drop and more shingles cases would occur. [47]
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