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Uncovering Truth is the Nature of Discovery. In microscopy, our mission is to empower you to drive progress in science. To help you get closer to the truth hidden in every sample, we have completely re-imagined confocal microscopy. Our family of confocal microscopes – STELLARIS 5 and STELLARIS 8 – takes confocal imaging to a new level.
STELLARIS. Confocal Microscope Platform. Next generation STELLARIS is a confocal microscope platform designed around your research needs. STELLARIS confocal microscopes can be combined with all Leica modalities, including FLIM, STED, MP, DLS, and CRS. The next generation STELLARIS confocal platform is your fast track to rewarding research. Power.
Confocal Laser Scanning Microscopy (CLSM) is one of a series of methods to generate slices from microscopic samples by means of optics. The sample stays intact, and the slicing may be repeated many times. True Confocal Scanning (TCS) is a technique, where only a single, diffraction limited spot is illuminated and observed at a time.
Fluorescence Recovery After Photobleaching (FRAP) has been considered the most widely applied method for observing translational diffusion processes of macromolecules. The resulting information can be used to determine kinetic properties, like the diffusion coefficient, mobile fraction, and transport rate of the fluorescently labeled molecules. FRAP employs irradiation of a fluorophore with a ...
When operating a confocal microscope, or when discussing features and parameters of such a device, we inescapably mention the pinhole and its diameter. This short introductory document is meant to explain the significance of the pinhole for those, who did not want to spend too much time to dig into theory and details of confocal microscopy but wanted to have an idea about the effect of the ...
This article outlines the most important sensors used in confocal microscopy. By confocal microscopy, we mean "True Confocal Scanning", i.e. the technique that illuminates and measures one single point only. The aim is not to impart in-depth specialist knowledge, but to give the user a small but clear overview of the differences between the various technologies and to advise on which sensor ...
Leica Microsystems. Light Sheet Microscopy. Confocal Microscopy. Depth of Field. 3D Imaging. 1. The vertical way – Confocal. Most commonly, we have confocal microscopy [1] in mind when referring to optical sectioning. The confocal principle is seamlessly integrated into standard-type light microscopes (although the technical integration ...
The LAS X Core Software has full image viewing capabilities, including annotations, image overlay and image comparison. It controls your Leica microscope. If you add a compatible Leica camera, you have a complete image acquisition station. Acquisition and advanced modules complement LAS X Core software and boost your imaging and analysis ...
Photomultiplier tubes (PMT) Probably the best-known sensor for confocal imaging so far, is the classical PMT (Fig 01), which started its career more than 80 years ago in the early 1930’s [1]. It is based on the photoelectric effect, first described by H. Hertz [2] and interpreted by A. Einstein [3].
The SP8 LIGHTNING confocal microscope allows you to make proper and detailed observations of fast biological processes. Your experimental work will have the benefit of super-resolution, high-speed imaging, and the capability to image multiple fluorescent markers simultaneously. Thanks to the exclusive detection concept of LIGHTNING, you can ...