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Scopolamine, also known as hyoscine, [9] or Devil's Breath, [10] is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is used as a medication to treat motion sickness [11] and postoperative nausea and vomiting.
Hyoscine butylbromide, also known as scopolamine butylbromide [4] and sold under the brandname Buscopan among others, [5] is an anticholinergic medication used to treat abdominal pain, esophageal spasms, bladder spasms, biliary colic, [6] and renal colic.
[1] [2] The GI cocktail is commonly prescribed in the hospital or emergency department, and has been used to help distinguish chest pain as either gastrointestinal or cardiac. [1] While it has been widely used in the treatment of dyspepsia, studies have suggested that the GI cocktail is only as effective as antacids alone.
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Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors. It was patented in 1902 and approved for medical use in 1947. [3]
Anticholinergic drugs [8] and deliriants: [9]. Atropine, racemic hyoscyamine, from the deadly nightshade (Atropa belladonna); Hyoscyamine, the levo-isomer of atropine, from henbane (Hyoscyamus niger), mandrake (Mandragora officinarum) and the sorcerers' tree (Latua pubiflora).
GLP-1 agonists like Ozempic have exploded over the past few years, thanks to data that show they can help people lose a significant amount of weight. But these medications aren’t perfect, and it ...
Scopine can be prepared by the hydrolysis of scopolamine. [ 1 ] [ 6 ] [ 7 ] It can also be prepared in three steps from N -methoxycarbonylpyrrole and 1,1,3,3-tetrabromoacetone ; the reagents are combined in a [4+3] cycloaddition , followed by a diastereoselective reduction with diisobutylaluminum hydride , and finally a Prilezhaev epoxidation ...