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  2. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. So, for example, digoxin has a half-life (or t ⁠ 1 / 2 ⁠ ) of 24–36 h; this means that a change in the dose will take the best part of a week to ...

  3. Half-life - Wikipedia

    en.wikipedia.org/wiki/Half-life

    For example, the medical sciences refer to the biological half-life of drugs and other chemicals in the human body. The converse of half-life (in exponential growth) is doubling time. The original term, half-life period, dating to Ernest Rutherford's discovery of the principle in 1907, was shortened to half-life in the early 1950s. [1]

  4. Effective half-life - Wikipedia

    en.wikipedia.org/wiki/Effective_half-life

    When radionuclides are used pharmacologically, for example in radiation therapy, they are eliminated through a combination of radioactive decay and biological excretion.An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay constants, as in the formula:

  5. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    A drug's characteristics make a clear distinction between tissues with high and low blood flow. Enzymatic saturation: When the dose of a drug whose elimination depends on biotransformation is increased above a certain threshold the enzymes responsible for its metabolism become saturated. The drug's plasma concentration will then increase ...

  6. Mounjaro, Zepbound: What Happens to Your Body When You ... - AOL

    www.aol.com/mounjaro-zepbound-happens-body-stop...

    This is a change that you’ll likely notice shortly after you’ve stopped taking the drug, as the half-life of tirzepatide is about one week. “This means that within four weeks, most of the ...

  7. Clearance (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Clearance_(pharmacology)

    There is an important relationship between clearance, elimination half-life and distribution volume. The elimination rate constant of a drug K e l {\displaystyle K_{el}} is equivalent to total clearance divided by the distribution volume

  8. Context-sensitive half-life - Wikipedia

    en.wikipedia.org/wiki/Context-sensitive_half-life

    Context-sensitive half-life or context sensitive half-time is defined as the time taken for blood plasma concentration of a drug to decline by one half after an infusion designed to maintain a steady state (i.e. a constant plasma concentration) has been stopped. The "context" is the duration of infusion.

  9. Chlordiazepoxide - Wikipedia

    en.wikipedia.org/wiki/Chlordiazepoxide

    The half-life of chlordiazepoxide is from 5 to 30 hours but has an active benzodiazepine metabolite, nordiazepam, which has a half-life of 36 to 200 hours. [31] The half-life of chlordiazepoxide increases significantly in the elderly, which may result in prolonged action as well as accumulation of the drug during repeated administration.