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Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (-pathy) or inflammation of the white matter (leuko-) of the brain (-encephalo-) at multiple locations (multifocal). It is caused by the JC virus, which is normally present and kept under control by the immune system. The ...
Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [ 5 ] of the cell nucleus.
First released as the Cleveland Clinic Bulletin in 1931, the publication was renamed the Cleveland Clinic Quarterly in 1932 and later rebranded as the CCJM in 1987. [ 1 ] CCJM is a peer-reviewed medical publication distributed monthly to over 123,000 healthcare professionals, including internists, hospitalists, cardiologists , endocrinologists ...
Cleveland Clinic Children's (CCC) is a pediatric acute care children's teaching hospital located in Cleveland, Ohio on the main campus of Cleveland Clinic. The hospital has 389 pediatric beds [ 87 ] and is affiliated with Cleveland Clinic Lerner College of Medicine , [ 13 ] Case Western Reserve University School of Medicine , Heritage College ...
Joseph R. Berger (born April 19, 1951) is an American internist and neurologist who is known [1] [non-primary source needed] [2] [non-primary source needed] for his research interests in progressive multifocal leukoencephalopathy (PML), the neurological complications of HIV/AIDS, multiple sclerosis, and other inflammatory disorders of the brain.
The Genomic Medicine Institute [1] at the Cleveland Clinic is an inter-disciplinary institute and department that focuses on patient care, patient-oriented research, and outreach and education in personalized healthcare guided by genetics and genomics.
Igor Koralnik is an American physician, neurologist and scientist. He is one of the first physicians to study the neurologic complications caused by the human immunodeficiency virus [1] and is a leading researcher [2] in the investigation of the polyomavirus JC (JC virus), which causes progressive multifocal leukoencephalopathy (PML), a disease of the central nervous system that occurs in ...
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