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Biosynthesis. Neurosteroids are synthesized from cholesterol, which is converted into pregnenolone and then into all other endogenous steroids. Neurosteroids are produced in the brain after local synthesis or by conversion of peripherally-derived adrenal steroids or gonadal steroids. They accumulate especially in myelinating glial cells, from ...
Steroidogenic enzymes are enzymes that are involved in steroidogenesis and steroid biosynthesis. [2][3][4][5] They are responsible for the biosynthesis of the steroid hormones, including sex steroids (androgens, estrogens, and progestogens) and corticosteroids (glucocorticoids and mineralocorticoids), as well as neurosteroids, from cholesterol ...
5α-Reductase is most known for converting testosterone, the male sex hormone, into the more potent dihydrotestosterone: Testosterone. Dihydrotestosterone. The major difference is the Δ 4,5 double-bond on the A (leftmost) ring. The other differences between the diagrams are unrelated to structure.
Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. [1] It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid ...
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, and lipid modulator. [2] A main target of PEA is proposed to be the peroxisome proliferator-activated receptor alpha (PPAR-α). [3][4] PEA also has affinity to cannabinoid-like G-coupled receptors GPR55 and GPR119. [5]
Pregnenolone (P5), or pregn-5-en-3β-ol-20-one, is an endogenous steroid and precursor / metabolic intermediate in the biosynthesis of most of the steroid hormones, including the progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. [1]
Allopregnanolone, a major endogenous inhibitory neurosteroid. Steroid ring system.. This is a list of neurosteroids, or natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors.
A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids.Neurosteroids include the excitatory neurosteroids pregnenolone sulfate, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S), and the inhibitory neurosteroids allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol, among others. [1]