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The prefrontal cortex has been defined based on cytoarchitectonics by the presence of a cortical granular layer IV.It is not entirely clear who first used this criterion. Many of the early cytoarchitectonic researchers restricted the use of the term prefrontal to a much smaller region of cortex including the gyrus rectus and the gyrus rostralis (Campbell, 1905; G. E. Smith, 1907; Brodmann ...
The medial prefrontal cortex (mPFC) is a subdivision of the prefrontal cortex. It encodes expected outcomes, both positive and negative, and signals when the expected outcomes do not occur. The mPFC, mediated by the amygdala, is also involved in the extinction and modulation of conditioned responses, including emotional ones, and the ...
Simplified diagram of frontal cortex to striatum to thalamus pathways. There are five defined frontostriatal circuits: motor and oculomotor circuits originating in the frontal eye fields are involved in motor functions; while dorsolateral prefrontal, orbital frontal, and anterior cingulate circuits are involved in executive functions, social behavior and motivational states. [2]
The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making. In non-human primates it consists of the association cortex areas Brodmann area 11 , 12 and 13 ; in humans it consists of Brodmann area 10 , 11 and 47 .
The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex. It is one of the four major dopamine pathways in the brain . It is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe), and is thought to be involved in cognitive control ...
The ventromedial prefrontal cortex (vmPFC) is a part of the prefrontal cortex in the mammalian brain. The ventral medial prefrontal is located in the frontal lobe at the bottom of the cerebral hemispheres and is implicated in the processing of risk and fear , as it is critical in the regulation of amygdala activity in humans. [ 2 ]
The prefrontal cortex, being a central hub for executive functions, relies on the input from the mesocortical pathway to modulate and fine-tune cognitive processes essential for goal-directed behavior and decision-making. [20] Dysregulation of the neurons in this pathway has been connected to ADHD. [16]
The prefrontal cortex plays a significant role in mediating executive functions. [121] [123] [124] Planning involves activation of the dorsolateral prefrontal cortex (DLPFC), anterior cingulate cortex, angular prefrontal cortex, right prefrontal cortex, and supramarginal gyrus. [124]