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Drugs can have various types of impact on the male body, side effects of medications may affect male fertility, spermatogenesis, and sexual function. Drugs can affect sperm parameters by inhibiting normal exocrine functions of the testes which can lead to a decrease in production of sperm, or by creating hormone imbalances. [4]
Terms oligospermia, oligozoospermia, and low sperm count refer to semen with a low concentration of sperm [1] and is a common finding in male infertility. Often semen with a decreased sperm concentration may also show significant abnormalities in sperm morphology and motility (technically oligoasthenoteratozoospermia ).
Aprocitentan, sold under the brand name Tryvio, is a medication used to treat hypertension (high blood pressure). [1] It is developed by Idorsia. [4] It is taken by mouth. [1] Aprocitentan is a receptor antagonist that targets both endothelin A and endothelin B receptors. [5] [6] Aprocitentan was approved for medical use in the United States in ...
At very high doses (400 mg/day), spironolactone has also been associated with testicular atrophy and reversibly reduced fertility, including semen abnormalities such as decreased sperm count and motility in cis men. [110] [111] However, such doses of spironolactone are rarely used clinically. [111]
A 2021 study, as well as earlier ones, found that cannabis use decreased the volume of semen and sperm count, and altered the sperm’s shape, for example.
Exposure to EDB has been shown to adversely affect male fertility by leading to a decreased sperm counts, decreased numbers of viable sperm and increased abnormal sperm morphology. [33] [34] The primary route of exposure is through inhalation. [32]
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Nearly 50 years of research links two common insecticides used in food, yards and households to dramatically lower sperm count in men worldwide, a new study found.