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Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014 1 Adalimumab: Humira Biologic Rheumatoid arthritis: AbbVie Inc. 14,012 1,469 2 Ledipasvir/sofosbuvir: Harvoni Small molecule Hepatitis C: Gilead Sciences: 13,864 11,737 3 Etanercept: Enbrel Biologic Rheumatoid arthritis: Amgen. Pfizer. 8,697 4,009 4 Infliximab ...
In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons [1]) organic compound that may regulate a biological process, with a size on the order of 1 nm [citation needed]. Many drugs are small molecules; the terms are equivalent in the literature.
[citation needed] The great majority of drugs on the market have molecular weights between 200 and 600 daltons, and particularly <500; [3] [4] they belong to the group of small molecules. A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five , which covers the numbers of hydrophilic groups, molecular ...
Chimeric small molecule therapeutics are a class of drugs designed with multiple active domains to operate outside of the typical protein inhibition model. While most small molecule drugs inhibit target proteins by binding their active site, chimerics form protein-protein ternary structures to induce degradation or, less frequently, other protein modifications.
RNA-targeting small molecules represent a class of small molecules, organic compounds with traditional drug properties (e.g., Lipinski's rule of five) that can bind to RNA secondary or tertiary structures and alter translation patterns, localization, and degradation.
This multi-page article lists pharmaceutical drugs alphabetically by name. Many drugs have more than one name and, therefore, the same drug may be listed more than once. Brand names and generic names are differentiated by capitalizing brand names. See also the list of the top 100 bestselling branded drugs, ranked by sales.
molecules with drug-like properties "ChEMBL". 1,961,000 cheML.io: Departments of Computer Science and Chemistry at Nazarbayev University de novo molecules generated by ML models SMILES, computed properties artificially generated "cheML.io". [3] 2,800,000 ChemDB chemical database small molecules "ChemDB". 5,000,000 ChemExper Chemexper Chemical ...
The drug payloads are highly active molecules that are too toxic to be administered in their untargeted forms at therapeutic dose levels [citation needed]. This modular approach allows varying targeting ligands, linker systems and drug payloads and generate SMDCs for different diseases. [1]