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The gonads develop from three sources; the mesothelium, underlying mesenchyme and the primordial germ cells. Gonads start developing as a common primordium (an organ in the earliest stage of development), in the form of genital ridges, [7] at the sixth week, which are only later differentiated to male or female sex organs (except when they are ...
The gonadal ridge, in turn, develops into a gonad. This is a testis in the male and an ovary in the female. At first, the mesonephros and gonadal ridge are continuous, but as the embryo grows the gonadal ridge gradually becomes pinched off from the mesonephros. However, some cells of mesonephric origin join the gonadal ridge.
Germ cells migrating to the gonads may not reach that intended destination and a tumor can grow wherever they end up, but the exact cause is still unknown. These tumors can be benign or malignant. [23] On arrival at the gonad, primordial germ cells that do not properly differentiate may produce germ cell tumors of the ovary or testis in a mouse ...
They differentiate in the gonads from primordial germ cells into gametogonia, which develop into gametocytes, which develop into the final gametes. [1] This process is known as gametogenesis. Germ cells pass on genetic material through the process of sexual reproduction. This includes fertilization, recombination and meiosis. These processes ...
Primordial germ cells are among the first lineages that are established in development [1] and they are the precursors for gametes. [2] It is thought that the process of primordial germ cell migration itself has been conserved rather than the specific mechanisms within it, as chemoattraction and repulsion seem to have been borrowed from blood cells, neurones, and the mesoderm. [1]
[1] [39] [40] On arrival at the gonads, human and mouse PGCs activate widely conserved germ cell-specific factors, and subsequently down-regulate the expression of pluripotency factors. [41] This transition results in the determination of germ cells, a form of cell commitment that is no longer reversible.
The reproductive system begins development at four to five weeks of gestation with germ cell migration. The bipotential gonad results from the collection of the medioventral region of the urogenital ridge. At the five-week point, the developing gonads break away from the adrenal primordium. Gonadal differentiation begins 42 days following ...
Sex cord–gonadal stromal tumour is a group of tumours derived from the stromal component of the ovary and testis, which comprises the granulosa, thecal cells and fibrocytes. [1] In contrast, the epithelial cells originate from the outer epithelial lining surrounding the gonad while the germ cell tumors arise from the precursor cells of the ...