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The ratio gives the relative hydrophobicity scale for individual amino acids. Computation was trained on high resolution protein crystal structures. This quantitative descriptor for microenvironment was derived from the octanol-water partition coefficient , (known as Rekker's Fragmental Constants) widely used for pharmacophores.
the population mean or expected value in probability and statistics; a measure in measure theory; micro-, an SI prefix denoting 10 −6 (one millionth) Micrometre or micron (retired in 1967 as a standalone symbol, replaced by "μm" using the standard SI meaning) the coefficient of friction in physics; the service rate in queueing theory
In practice, this is inferred by the detection of only one of the mutually exclusive antibody light chains, kappa or lambda, on the entire population of the abnormal B cells. Normal B lymphocytes consist of a stew of different antibody-producing cells, resulting in a mixture of both kappa- and lambda-expressing cells.
The foodstuffs listed for comparison show the essential amino acid content per unit of the total protein of the food, 100g of spinach, for example, only contains 2.9g of protein (6% Daily Value), and of that protein 1.36% is tryptophan. [2] [7] (note that the examples have not been corrected for digestibility)
Amino acid replacement is a change from one amino acid to a different amino acid in a protein due to point mutation in the corresponding DNA sequence. It is caused by nonsynonymous missense mutation which changes the codon sequence to code other amino acid instead of the original.
The structure of the inactive μ-opioid receptor has been determined with the antagonists β-FNA [6] and alvimopan. [7] Many structures of the active state are also available, with agonists including DAMGO, [8] β-endorphin, [9] fentanyl and morphine. [10]
In biochemistry, the σ factor (or specificity factor) is a protein found in RNA polymerase. In bone physiology, the bone remodeling period—i.e., the life span of a basic multicellular unit—has historically been referred to as the sigma period. In early 20th-century physiology literature, σ had been used to represent milliseconds. [13]
The 89 kDa fragment includes the auto-modification domain and catalytic domain. The putative mechanism of PCD activation via PARP inactivation relies on the separation of the DNA-binding region and the auto-modification domain. The DNA-binding region is capable of doing so independent of the rest of the protein, cleaved or not.