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These largely occurred among kids younger than 5 years old. In any case, melatonin should be thought of as a short-term method to help sleep, not a long-term sleeping pill for you or your kids ...
Melatonin overdoses in kids are on the rise. A top sleep expert on inaccurate labels and what parents should do before using these supplements with their kids. Experts Don't Actually Know If ...
One expert says the sleep aid is "overused" by some families.
Increased use of melatonin in the 21st century has significantly increased reports of melatonin overdose, calls to poison control centers, and related emergency department visits for children. The number of children who unintentionally ingested melatonin supplements in the US has increased 530% from 2012 to 2021.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
[1] 6-Hydroxymelatonin is produced as a result of the enzymatic conversion of melatonin through hydroxylation. [2] Similar to melatonin, 6-OHM is a full agonist of the MT 1 and MT 2 receptors. [3] [4] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin. [5] [6]