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Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, [1] but are now known to also be expressed during other stresses including exposure to cold, [2] UV light [3] and during wound healing or tissue remodeling. [4]
Chaperonins are characterized by their barrel-shaped structure with binding sites for client proteins inside the barrels. The human HSP90 group consists of 5 members according to the HGNC: [17] [18] HSP90AA1 (heat shock protein 90 kDa alpha, class A, member 1) HSP90AA3P (heat shock protein 90 alpha family class A member 3, pseudogene)
Heat shock proteins induced by the HSR can help prevent protein aggregation that is associated with common neurodegenerative diseases such as Alzheimer's, Huntington's, or Parkinson's disease. [8] The diagram depicts actions taken when a stress is introduced to the cell. Stress will induce HSF-1 and cause proteins to misfold.
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins required for tumor growth, which is why Hsp90 inhibitors are investigated as anti-cancer drugs.
Download as PDF; Printable version; ... Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene. [5] [6] [7]
3306 15512 Ensembl ENSG00000126803 ENSMUSG00000059970 UniProt P54652 P17156 RefSeq (mRNA) NM_021979 NM_001387931 NM_001002012 NM_008301 RefSeq (protein) NP_068814 NP_001002012 NP_032327 Location (UCSC) Chr 14: 64.54 – 64.55 Mb Chr 12: 76.45 – 76.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock-related 70 kDa protein 2 is a protein that in humans is encoded by the ...
3320 15519 Ensembl ENSG00000080824 ENSMUSG00000021270 UniProt P07900 P07901 RefSeq (mRNA) NM_001017963 NM_005348 NM_010480 RefSeq (protein) NP_001017963 NP_005339 NP_034610 Location (UCSC) Chr 14: 102.08 – 102.14 Mb Chr 12: 110.66 – 110.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene ...
Hsp20, like all heat shock proteins, is in abundance when cells are under stressed conditions. [4] Hsp20 is known to be expressed in many human tissues, including the brain and heart. [ 5 ] Hsp20 has been studied extensively in cardiac myocytes and is known to act as a chaperon protein, binding to protein kinase 1 (PDK1) and allowing its ...