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This slows down communication between neurons and the nervous system. [13] Unlike benzodiazepines, which increase the frequency of the chloride channel opening, carisoprodol increases the duration of channel opening when GABA is bound. [14] [15] GABA is the main inhibitory neurotransmitter in the nervous system, which causes its depressant effects.
Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death. It is the result of inhibited or suppressed brain activity. [1]
Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C , [ 1 ] but also 5-HT 3 , [ 1 ] 5-HT 6 , and/or 5-HT 7 in some cases.
Despite cytokines often being too large to pass through the blood-brain barrier alone, [78] their effect on the central nervous system (CNS) can happen with cytokines entering the CNS in areas where the blood-brain barrier is permeable, by being carried across the blood-brain barrier, or by binding with the cerebral vascular endothelium ...
The range of possible mechanisms includes (1) nonspecific neurological effects (e.g., sedation) that globally impair behavior including sexual function; (2) specific effects on brain systems mediating sexual function; (3) specific effects on peripheral tissues and organs, such as the penis, that mediate sexual function; and (4) direct or ...
Exposure to light also targets the serotonergic system, providing more support for the important role this system may play in depression. [27] Sleep deprivation and light therapy both target the same brain neurotransmitter system and brain areas as antidepressant drugs, and are now used clinically to treat depression. [28]
It acts as a central nervous system depressant, which means it slows brain activity, causing your muscles to relax and making you feel calm. It can elevate mood, curb anxiety, relieve pain, and ...
Depressants reduce, or depress, activity and stimulation in the central nervous system. This category encompasses a spectrum of substances with sedative, soporific, and anesthetic properties, and include sedatives , hypnotics , and opioids .