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Transdermal estradiol gel produces an estradiol to estrone ratio of about 1:1. [10] [12] Transdermal estradiol gel can be used as a form of high-dose estrogen in transgender women. [224] However, the doses needed require application to a large surface of skin that amounts to the combined area of both legs for proper absorption. [224]
The first transdermal estradiol gel, a hydroalcoholic gel known as EstroGel, was initially described in 1980 and was introduced in Europe around 1981. [223] Transdermal estradiol gel did not become available in the United States until 2004, when EstroGel was introduced in this country as well. [223]
A combination of segesterone acetate and the estrogen estradiol is under development in a transdermal gel formulation for use as a contraceptive in women by the Population Council in conjunction with Antares Pharma in the United States and Europe. [12] [14] As of December 2017, it is in phase III clinical trials for this indication. [12]
Estradiol: 25 μg/day b: 50 μg/day b: 100 μg/day b: Transdermal gel: Estradiol: 0.5 mg/day: 1–1.5 mg/day: 2–3 mg/day Vaginal: Estradiol: 25 μg/day – – Estriol: 30 μg/day: 0.5 mg 2x/week: 0.5 mg/day IM Tooltip Intramuscular or SC injection: Estradiol valerate – – 4 mg 1x/4 weeks Estradiol cypionate: 1 mg 1x/3–4 weeks: 3 mg 1x/3 ...
In general, generic estradiol cream may be more affordable than brand-name versions. This is because, as per the Food and Drug Administration (FDA), generic drugs may cost around 80% to 85% less ...
Estrogen: TD patch: 25–400 μg/day Divigel [c] Estrogen: TD gel: 0.5–5 mg/day Various: Estrogen: SC implant: 50–200 mg every 6–24 mos Estradiol valerate: Progynova: Estrogen: Oral: 2–10 mg/day Progynova: Estrogen: Sublingual: 1–8 mg/day Delestrogen [c] Estrogen: IM, SC: 2–10 mg/wk or 5–20 mg every 2 wks Estradiol cypionate: Depo ...