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It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce necroptosis by interaction with RIPK1 and MLKL in a protein complex termed the necrosome. [7] Interactions between RIPK1 and RIPK3 also form a necrosome, which triggers apoptosis. [9] The red highlighted region of RIPK3 represents the Protein ...
RIPK1 protein is composed of 671 amino acids, and has a molecular weight of about 76 kDa. It contains a serine/threonine kinase domain (KD) in the 300 aa N-Terminus, a death domain (DD) in the 112 aa C-Terminus, and a central region between the KD and DD called intermediate domain (ID).
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PANoptosis is a prominent innate immune, inflammatory, and lytic cell death pathway initiated by innate immune sensors and driven by caspases and receptor-interacting protein kinases (RIPKs) through multiprotein PANoptosome complexes.
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
Miranda Caroline Raison was born in Burnham Thorpe. [5] Her mother is former Anglia News reader Caroline Raison (née Harvey). [5]Her father, Nick Raison, is a jazz pianist who accompanied the BBC National Orchestra of Wales [6] when Raison played a showgirl in the Doctor Who episodes "Daleks in Manhattan" and "Evolution of the Daleks".
Matthew Ray Prokop (born July 29, 1990) [1] is an American former actor. He is known for his roles as Jimmie "The Rocket Man" Zara in the Disney film High School Musical 3: Senior Year (2008) and Josh Rosen in the Disney Channel Original Movie Geek Charming (2011).
Clarence Williams III (August 21, 1939 – June 4, 2021) was an American actor. He played the character of Linc Hayes in the police television series The Mod Squad from 1968 to 1973.