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The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the liver, kidney, spleen, and bone marrow.
Ancient history – Aggregate of past events from the beginning of recorded human history and extending as far as the Early Middle Ages or the Postclassical Era. The span of recorded history is roughly five thousand years, beginning with the earliest linguistic records in the third millennium BC in Mesopotamia and Egypt .
Timelines of world history; List of timelines; Chronology; See calendar and list of calendars for other groupings of years. See history, history by period, and periodization for different organizations of historical events. For earlier time periods, see Timeline of the Big Bang, Geologic time scale, Timeline of evolution, and Logarithmic timeline
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
The timeline of the evolutionary history of life represents the current scientific theory outlining the major events during the development of life on planet Earth. Dates in this article are consensus estimates based on scientific evidence , mainly fossils .
These timelines of world history detail recorded events since the creation of writing roughly 5000 years ago to the present day. For events from c. 3200 BC – c. 500 see: Timeline of ancient history; For events from c. 500 – c. 1499, see: Timeline of post-classical history; For events from c. 1500, see: Timelines of modern history
In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes. [1] [2] [3] Some sources prefer the term "CFU-Mega". [4]
The timeline of human evolution outlines the major events in the evolutionary lineage of the modern human species, Homo sapiens, throughout the history of life, beginning some 4 billion years ago down to recent evolution within H. sapiens during and since the Last Glacial Period.