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According to a 2013 analysis of extramural clinical trials supported by the NHLBI, [116] the components of the WHI study have been some of the most frequently cited in the literature, with the E+P trial ranking first among all NHLBI-sponsored clinical trials, alone averaging 812.5 citations annually (total average annual number of citations for ...
Death rate from obesity, 2019. Obesity is a risk factor for many chronic physical and mental illnesses.. The health effects of being overweight but not obese are controversial, with some studies showing that the mortality rate for individuals who are classified as overweight (BMI 25.0 to 29.9) may actually be lower than for those with an ideal weight (BMI 18.5 to 24.9). [1]
Mild calorie restriction may be beneficial for pregnant women to reduce weight gain (without weight loss) and reduce perinatal risks for both the mother and child. [11] [12] For overweight or obese individuals, calorie restriction may improve health through weight loss, although a gradual weight regain of 1–2 kg (2.2–4.4 lb) per year may occur.
Historically, clinical trials were offered to men, not women. In the 1990s, the National Institutes of Health began requiring that women be included. However, gender inequity still exists.
The World Health Organization (WHO) estimated that nearly 2 billion adults worldwide, aged 18 years and older, were overweight in 2016. [ 22 ] According to the National Health and Nutrition Examination Survey (NHANES), an estimated 71.6% of the United States' adult population aged 20 and over is considered either overweight or obese, and this ...
Clinical trials are medical research studies conducted on human subjects. [1] The human subjects are assigned to one or more interventions, and the investigators evaluate the effects of those interventions. [1] [2] The progress and results of clinical trials are analyzed statistically. [3] [4]
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The obesity paradox (excluding the cholesterol paradox) was first described in 1999 in overweight and obese people undergoing hemodialysis, [10] and has subsequently been found in those with heart failure, [5] [11] [12] myocardial infarction, [13] acute coronary syndrome, [14] chronic obstructive pulmonary disease (COPD), [15] pulmonary ...
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