Ads
related to: can dna damage cause cancer to happen in women over 50- Cancer Genomics
Want to compare library methods?
Watch our featured webinar now.
- Trusted Answers
Superior performance and outcomes.
For your most critical challenges.
- Featured Products
Discover a portfolio of solutions.
Answers to your research questions.
- Request A Quote
Start a quote with Agilent today.
For your lab management needs.
- Cancer Genomics
cancer.osu.edu has been visited by 10K+ users in the past month
Search results
Results From The WOW.Com Content Network
The schematic diagram indicates the roles of insufficient DNA repair in aging and cancer, and the role of apoptosis in cancer prevention. An excess of naturally occurring DNA damage, due to inherited deficiencies in particular DNA repair enzymes, can cause premature aging or increased risk for cancer (see DNA repair-deficiency disorder).
Ionizing radiation may be used to treat other cancers, but this may, in some cases, induce a second form of cancer. [74] Radiation can cause cancer in most parts of the body, in all animals, and at any age, although radiation-induced solid tumors usually take 10–15 years, and can take up to 40 years, to become clinically manifest, and ...
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
DNA damage can initiate the development of cancer or other aging related diseases depending on several factors. These include the type, amount, and location of the DNA damage in the body, the type of cell experiencing the damage and its stage in the cell cycle, and the specific DNA repair processes available to react to the damage. [11]
Tobacco smoke causes increased exogenous DNA damage, and these DNA damages are the likely cause of lung cancer due to smoking. [20] UV light from solar radiation causes DNA damage that is important in melanoma. [21] Helicobacter pylori infection produces high levels of reactive oxygen species that damage DNA and contributes to gastric cancer. [22]
This advantage to the cell is disadvantageous to the whole organism because such mutant cells can give rise to cancer. Thus, DNA damage in frequently dividing cells, because it gives rise to mutations, is a prominent cause of cancer. In contrast, DNA damage in infrequently-dividing cells is likely a prominent cause of aging. [17]