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Synaptic pruning has been suggested to have a role in the pathology of neurodevelopmental disorders such as schizophrenia, as well as in autism spectrum disorder. [ 18 ] [ 19 ]
mTOR is implicated in the failure of a 'pruning' mechanism of the excitatory synapses in autism spectrum disorders. ... Synaptic plasticity is a key contributor to ...
Synaptogenesis is particularly important during an individual's critical period, during which there is a certain degree of synaptic pruning due to competition for neural growth factors by neurons and synapses. Processes that are not used, or inhibited during their critical period will fail to develop normally later on in life.
Perceptual narrowing is a developmental process during which the brain uses environmental experiences to shape perceptual abilities. This process improves the perception of things that people experience often and causes them to experience a decline in the ability to perceive some things to which they are not often exposed.
The amygdala, cerebellum, and many other brain regions have been implicated in autism. [15]Unlike some brain disorders which have clear molecular hallmarks that can be observed in every affected individual, such as Alzheimer's disease or Parkinson's disease, autism does not have a unifying mechanism at the molecular, cellular, or systems level.
Synaptic defects are causally associated with early appearing neurological diseases, including autism spectrum disorders (ASD), schizophrenia (SCZ), and bipolar disorder (BP). Synaptic dysfunction, or synaptopathy, is often implicated in late-onset neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's, but the exact ...
He said some doctors will use it to treat anxiety disorders and migraines. "They have quite a bit of extensive utilization because of their ability to treat a number of disorders," Churchwell said.
Examples include autism spectrum disorder [5] and schizophrenia. [6] Synaptic dysfunction can also occur in neurodegenerative disorders such as Alzheimer's. [7] Immune-mediated cerebellar ataxias represent a group of disorders causing cerebellar ataxia induced by a dysfunction of synapses. [8]