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These charts include Non-DOT testing with urine, hair and oral fluid as well as DOT regulated testing. Drug testing can detect the presence of drugs and drug metabolites by using cutoff levels to determine if a specimen tests positive or negative for use of specific types of drugs.
Identify how to determine new vs. residual use of marijuana in a patient. Describe how to calculate the carboxy-tetrahydrocannabinol (carboxy-THC) to creatinine ratio along with a decision ratio and demonstrate its clinical utility.
Drug plus Metabolite: >3.0 μg/mL. 20-30 ng/mL. 10-50 ng/mL. 50 ng/mL (GC-MS; LC-MS/MS)
In regular users (more than once a week), the marijuana metabolite THC-COOH builds up to a high level, often on the order of hundreds of nanograms per milliliter (ng/ml), from which it may take weeks to decline back below the threshold of detection.
Confi rmation results by Gas Chromatography-Mass Spectrometry (GC-MS) or Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) vary by laboratory.
Urine drug testing for marijuana is based on THC’s main metabolite 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid. 7,118 Initial testing through immunoassay is sensitive to several THC metabolites and the federal cutoff level is 50 ng/mL although some laboratories may use a lower cutoff level of 20 ng/mL. 7 Confirmation testing via GC ...
We test for specific drugs and/or drug metabolites that are most useful in implying ingestion or exposure of substances of abuse. For example, there are many different substances that fall under the amphetamine drug class, but we only test for amphetamine, MDA, MDEA, MDMA, and methamphetamine. (Figure 2).
Following a dose of THC, the metabolite typically appears in the urine within 60 minutes, but can take as long as 4 hours. Note: The presence of the major THC-COOH > LOQ indicates exposure to THC within 3 days after a single use, to approximately 30 days in heavy chronic users.
In federal drug-free workplace programs, the cutoff for an initial test of marijuana metabolites is 50 nanograms per milliliter (ng/mL), while the cutoff for confirmatory testing is 15 ng/mL. Testing negative on a marijuana test indicates that the cannabinoids or metabolites measured were not found in the test sample.
The test can find out if THC or related chemicals from marijuana called metabolites are in your urine. The test is considered quite accurate. You may have to do the urine test in a healthcare provider's office or with a technician present.