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THC, CBD, and terpene profiles are more likely to predict the effects of the high than strain names or categorizations such as ‘indica,’ sativa,’ or ‘hybrid.’
The phrase entourage effect was introduced in 1999. [9] [10] While originally identified as a novel method of endocannabinoid regulation by which multiple endogenous chemical species display a cooperative effect in eliciting a cellular response, the term has evolved to describe the polypharmacy effects of combined cannabis phytochemicals or whole plant extracts. [11]
Two extracts of cannabis – dronabinol and nabilone – are approved by the FDA as medications in pill form for treating the side effects of chemotherapy and AIDS. [119] Short-term use increases both minor and major adverse effects. [116] Common side effects include dizziness, feeling tired, vomiting, and hallucinations. [116]
Broad-leafed C. indica plants in the Indian Subcontinent are traditionally cultivated for the production of charas, a form of hashish. Pharmacologically, C. indica landraces tend to have higher THC content than C. sativa strains. [15] [16] Some users report more of a "stoned" feeling and less of a "high" from C. indica when compared to C. sativa.
The effects of Indica varieties are usually soothing and relaxing, with some strains inducing even sedative effects. Therefore, if you want a boost to be more active or creative, Sativa might be ...
"Skunk" refers to several named strains of potent cannabis, grown through selective breeding and sometimes hydroponics. It is a cross-breed of Cannabis sativa and C. indica (although other strains of this mix exist in abundance). Skunk cannabis potency ranges usually from 6% to 15% and rarely as high as 20%.