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Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [8] It is primarily used to treat major depressive disorder and, perhaps more-especially, obsessive–compulsive disorder (OCD), [9] but is also used to treat anxiety disorders [10] such as panic disorder, social anxiety disorder, and post-traumatic stress ...
The saying “knowledge is power” applies well in certain situations — like becoming a leader in your field of expertise or knowing the best places to eat (we all have different skills).
SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the presynaptic cell. [2] They have varying degrees of selectivity for the other monoamine transporters , with pure SSRIs having strong affinity for the serotonin transporter and only weak affinity for the norepinephrine and ...
Dosage range (mg/day) [4] ~80% SERT occupancy (mg/day) [5] [6] Ratio (dosage / 80% occupancy) Citalopram: 20–40: 40: 0.5–1 Escitalopram: 10–20: 10: 1–2 Fluoxetine: 20–80: 20: 1–4 Fluvoxamine: 50–350: 70: 0.71–5 Paroxetine: 10–60: 20: 0.5–3 Sertraline: 25–200: 50: 0.5–4 Duloxetine: 20–120: 30: 0.67–2 Venlafaxine: 75 ...
Higher dosage does, however, increase the incidence and severity of adverse events associated with excessive 5-HT re-uptake inhibition. [6] Figure 2 Inhibition of re-uptake transport proteins, e.g. SERT, results in increased concentration of neurotransmitters, e.g. 5-HT, in the synaptic cleft, leading to improvement of depression symptoms
Trazodone is provided as the hydrochloride salt and is available in the form of 50 mg, 100 mg, 150 mg, and 300 mg oral tablets. [6] In Italy, it is also available as an oral solution (Trittico 60 mg/mL) with a dosing pipette marked at 25 mg and 50 mg. [51] An extended-release oral tablet formulation at doses of 150 mg and 300 mg is also available.
Inhibitors of these enzymes, e.g. the SSRI antidepressant fluvoxamine, reduce its clearance and can lead to an increase in agomelatine exposure, and possibly serotonin syndrome . [ 2 ] [ 29 ] There is also the potential for agomelatine to interact with alcohol to increase the risk of hepatotoxicity .
In vitro binding of fluvoxamine to human plasma proteins is 80%, and the volume of distribution is estimated to be 20 L/kg". How can it take "one week" or was the 5 days just rounded up just in case? Could this explain it, from the same PDF: "Metabolism The pharmacokinetics of fluvoxamine is linear between single oral doses of 25-100 mg.
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