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At high doses, prescription amphetamines, used to treat ADHD could increase a person’s risk of psychosis. Image credit: visualspace/Getty Images.
Taking a high dose of ADHD drugs is linked to more than five times greater risk of developing psychosis or mania, according to a new study published Thursday in the American Journal of Psychiatry.
A stimulant is a drug that stimulates the central nervous system, increasing arousal, attention and endurance. Stimulants are used in psychiatry to treat attention deficit-hyperactivity disorder. Because the medications can be addictive, patients with a history of drug abuse are typically monitored closely or treated with a non-stimulant.
Stimulant psychosis is a mental disorder characterized by psychotic symptoms (such as hallucinations, paranoid ideation, delusions, disorganized thinking, grossly disorganized behaviour). It involves and typically occurs following an overdose or several day binge on psychostimulants , [ 1 ] although it can occur in the course of stimulant ...
The National Institute of Mental Health recommends stimulants for the treatment of ADHD, and states that, "under medical supervision, stimulant medications are considered safe". [59] A 2007 drug class review found no evidence of any differences in efficacy or side effects in the stimulants commonly prescribed. [60]
Some physicians may prescribe a stimulant to treat the side effects of another psychiatric medication or to enhance it. This is sometimes called a “prescribing cascade," Moore said.
Doctors may prescribe non-stimulants including atomoxetine when a person has bothersome side effects from stimulants; when a stimulant was not effective; in combination with a stimulant to increase effectiveness; [31] [32] when the cost of stimulants is prohibitive; or when there is concern about the abuse potential of stimulants in a patient ...
Due to a wide range of observed side-effects, flibanserin's safety has been called into question. Clinical trials reported adverse reactions including dizziness, nausea, fatigue, and insomnia. [16] Hypotension and central nervous system depression (somnolence) leading to sedation and sleepiness symptoms were also observed. [16]