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[44] [45] Less common side effects (experienced by less than 5% of patients) include loss of appetite, nervousness, abdominal pain, diarrhea, urinary retention, dyspnea, and hiccups. [46] Most side effects generally become less intense over time, although issues related to constipation are likely to continue for the duration of use. [47]
A 2005 Cochrane review states that low level laser therapy can be tried to improve pain and morning stiffness due to rheumatoid arthritis as there are few side-effects. [ 160 ] There is limited evidence that tai chi might improve the range of motion of a joint in persons with rheumatoid arthritis.
The psychological effects of feminizing hormone therapy are harder to define than physical changes. Because hormone therapy is usually the first physical step taken to transition, the act of beginning it has a significant psychological effect, which is difficult to distinguish from hormonally induced changes.
This requires them to increase their drug dosage to maintain the benefit, and that in turn also increases the unwanted side effects. [72] Long-term opioid use can cause opioid-induced hyperalgesia, which is a condition in which the patient has increased sensitivity to pain. [95] All of the opioids can cause side effects. [64]
The hormonal effects of quercetin found in animal studies raise the suspicion of a parallel effect in humans, particularly in respect of estrogen-dependent tumors. [38] Quercetin supplementation can interfere with the effects of medications. The precise nature of this interaction is known for some common medicines, but for many, it is not. [38]
troublesome side effects of oral morphine, hydromorphone, or oxycodone. [ 49 ] [ 50 ] When using the transdermal patch, patients must be careful to minimize or avoid external heat sources (direct sunlight, heating pads, etc.), which can trigger the release and absorption of too much medication and cause potentially deadly complications.